Alfonso Lampen Selected Research

senecionine (integerrimine)

1/2020	The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.
1/2020	Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study.

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Alfonso Lampen Research Topics

Disease

16	Body Weight (Weight, Body) 01/2020 - 04/2011
9	Neoplasms (Cancer) 01/2019 - 04/2011
7	Breast Neoplasms (Breast Cancer) 01/2015 - 10/2005
5	Fatty Liver 01/2022 - 01/2018
5	Colonic Neoplasms (Colon Cancer) 03/2017 - 05/2012
4	Carcinogenesis 01/2019 - 05/2008
2	Necrosis 01/2020 - 05/2019
2	Cholestasis 01/2020 - 05/2019
2	Colorectal Neoplasms (Colorectal Cancer) 12/2019 - 05/2012
2	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2019 - 01/2018
2	Hepatocellular Carcinoma (Hepatoma) 04/2018 - 11/2012
2	Neural Tube Defects (Exencephaly) 03/2017 - 04/2006
2	Vomiting 08/2016 - 03/2014
2	Nausea 08/2016 - 03/2014
2	Coronary Disease (Coronary Heart Disease) 03/2015 - 01/2013
2	Teratocarcinoma 02/2006 - 04/2003
1	Iron Deficiencies 01/2020
1	Hypertrophy 01/2019
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 05/2018
1	Poisoning 05/2018
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Inflammation (Inflammations) 01/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2018
1	Hypertension (High Blood Pressure) 03/2017
1	Weight Loss (Weight Reduction) 03/2017
1	Myocardial Infarction 03/2017
1	Cardiac Arrhythmias (Arrythmia) 03/2017
1	Muscle Cramp (Cramp) 01/2017
1	Shellfish Poisoning 08/2016
1	Colic (Abdominal Cramps) 08/2016
1	Adenocarcinoma 03/2015
1	Renal Insufficiency (Renal Failure) 01/2015
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2015
1	Stomach Ulcer (Gastric Ulcer) 01/2015

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2005
7	alpha-ChlorohydrinIBA 01/2018 - 04/2011
4	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2022 - 01/2018
4	monochloropropanediolIBA 11/2018 - 08/2017
3	Triglycerides (Triacylglycerol)IBA 01/2022 - 01/2018
3	Pyrrolizidine AlkaloidsIBA 01/2020 - 04/2018
3	EstersIBA 01/2019 - 12/2015
3	Fatty Acids (Saturated Fatty Acids)IBA 06/2018 - 03/2015
3	Folic Acid (Vitamin M)FDA LinkGeneric 12/2017 - 05/2012
3	CarcinogensIBA 04/2011 - 10/2005
3	Valproic Acid (Depakote)FDA LinkGeneric 04/2006 - 04/2003
2	senecionine (integerrimine)IBA 01/2020 - 01/2020
2	glycidolIBA 01/2019 - 04/2011
2	LipidsIBA 01/2018 - 01/2018
2	MicroRNAs (MicroRNA)IBA 12/2017 - 03/2015
2	Okadaic AcidIBA 08/2016 - 03/2014
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 12/2014 - 08/2010
2	benzocycloheptapyridineIBA 05/2012 - 10/2005
2	Sulfates (Sulfates, Inorganic)IBA 08/2010 - 04/2007
2	Benzo(a)pyreneIBA 08/2010 - 04/2007
2	Anticonvulsants (Antiepileptic Drugs)IBA 02/2006 - 04/2003
1	clothianidinIBA 05/2020
1	thiaclopridIBA 05/2020
1	enilconazole (imazalil)IBA 05/2020
1	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2020
1	Biological ProductsIBA 01/2020
1	heliotrineIBA 01/2020
1	lasiocarpineIBA 01/2020
1	senkirkineIBA 01/2020
1	echimidineIBA 01/2020
1	Ferritins (Ferritin)IBA 01/2020
1	platyphyllineIBA 01/2020
1	Liver X ReceptorsIBA 01/2020
1	Bile Acids and Salts (Bile Acids)IBA 12/2019
1	TeaIBA 05/2019
1	methylamphotericin B (AME)IBA 05/2019
1	CateninsIBA 01/2019
1	Threonine (L-Threonine)FDA Link 01/2019
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2019
1	Serine (L-Serine)FDA Link 01/2019
1	Hemoglobins (Hemoglobin)IBA 01/2019
1	TriazolesIBA 01/2019
1	ManganeseIBA 01/2019
1	cyproconazoleIBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2018
1	Estrogens (Estrogen)FDA Link 01/2018
1	QuercetinIBA 01/2018
1	SilverIBA 01/2018
1	XenobioticsIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	furfuryl alcoholIBA 12/2017
1	Ethanol (Ethyl Alcohol)IBA 12/2017
1	Fomepizole (Antizol)FDA LinkGeneric 12/2017
1	Caffeine (No Doz)FDA LinkGeneric 03/2017
1	VitaminsIBA 03/2017
1	Synephrine (Oxedrine)IBA 03/2017
1	CreatineIBA 01/2017
1	Hydrogen Cyanide (Zyklon B)IBA 03/2016
1	GlucosidasesIBA 03/2016
1	Cyanides (Isocyanides)IBA 03/2016
1	cyanogenic glycosidesIBA 03/2016
1	NitritesIBA 01/2015
1	Estrogen ReceptorsIBA 01/2015

Therapy/Procedure

1	Oral Administration 06/2018